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目的探讨新生儿严重感染早期诊断快速、可靠的方法和测定降钙素原(PCT)在新生儿严重感染中的临床意义。方法对我院新生儿科的121例新生儿进行PCT、C反应蛋白(CRP)、白细胞介素6(IL-6)的测定,分为重症感染、局部感染和非感染3组进行分析。结果重症感染时,血清PCT、CRP和IL-6浓度均明显升高,与局部感染组和非感染组比较差异均有统计学意义(P<0.01)。结论PCT在新生儿严重细菌感染早期即升高,可作为新生儿重症感染早期诊断的标志物,PCT的动态变化可作为严重感染预后的指标,持续升高提示预后差。
Objective To investigate the rapid and reliable method for the early diagnosis of severe neonatal infection and to determine the clinical significance of procalcitonin (PCT) in the severe neonatal infection. Methods 121 cases of neonates in our hospital were examined for PCT, C-reactive protein (CRP) and interleukin-6 (IL-6), and divided into severe infection, local infection and non-infection. Results Serum PCT, CRP and IL-6 levels were significantly increased in severe infection, with statistical significance (P <0.01) compared with those in local infection group and non-infected group. Conclusions PCT is elevated early in severe neonatal infections and can be used as a marker for early diagnosis of severe neonatal infections. The dynamic changes of PCT can be used as indicators of severe infection prognosis.