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选用未经产雌性昆明种小鼠，取未孕及孕４～８ｄ 的子宫作切片，用免疫组化染色及图像分析法观察着床前后子宫内膜中层粘连蛋白（ＬＮ）和纤连蛋白（ＦＮ）的分布状况及含量变化，探讨它们与着床过程的相关关系。结果显示，在未孕子宫，ＬＮ 主要分布于各类上皮基膜中，ＦＮ 存在于基膜和基质细胞之间；着床前后，各类上皮基膜中ＬＮ、ＦＮ 含量明显增多，与未孕小鼠差异有显著性。随着蜕膜发育，蜕膜细胞周围出现ＬＮ 和ＦＮ，呈不甚连续的线样膜环绕蜕膜细胞。ＬＮ 及ＦＮ 在着床前后子宫内膜中表达增多，提示这两种物质与着床过程及蜕膜细胞的功能有关
Uterus from unfertilized pregnant women and from 4 to 8 days of pregnancy were selected for the study. Immunohistochemical staining and image analysis were used to observe the expression of laminin (LN) and fibronectin (LN) in the endometrium before and after implantation FN) distribution and content changes, to explore their relationship with implantation process. The results showed that in the uterus without uterus, LN mainly distributed in various types of epithelial basement membrane, FN exists between the basement membrane and stromal cells; before and after implantation, various types of epithelial basement membrane LN, FN content was significantly increased, and not pregnant There was significant difference in mice. With the development of decidua, there are LN and FN around the decidual cells, showing a less continuous linear sample surrounding the decidual cells. LN and FN in the endometrium before and after implantation increased, suggesting that these two substances and the implantation process and the function of decidual cells