利尿剂治疗高血压的机理是很多研究的主题,排盐利尿剂治疗开始时,血压急性下降与利尿剂引起水和盐的消耗有关。在慢性噻嗪治疗时,血浆和细胞外液容积是有争论的。噻嗪类治疗高血压常伴有肾索一醛酮系统的活化,后者可以减低抗高血压的作用,很早的研究证明了血浆肾素活性和醛固酮的急性反应与双氢克尿噻引 The mechanism of diuretic treatment of hypertension is the subject of much research. The onset of paraquat diuretics at the onset of an acute decline in blood pressure is related to the consumption of water and salt by diuretics. Plasma and extracellular fluid volumes are controversial when treated with chronic thiazide. Thiazide treatment of hypertension is often accompanied by the activation of the renal cable an aldehyde ketone system, the latter can reduce the antihypertensive effect, early studies have shown that plasma renin activity and aldosterone acute reaction with hydrochlorothiazide