论文部分内容阅读
目的探讨新生儿黄疸血清总胆汁酸(TBA)和胆红素(BIL)变化特点及临床意义。方法 120例新生儿黄疸患儿,其中生理性黄疸患儿68例(生理性黄疸组)、病理性黄疸患儿52例(病理性黄疸组),选取同期60例健康新生儿为对照组。采用循环酶速率法测定三组新生儿血清TBA水平,采用矾酸盐氧化法测定三组新生儿血清总胆红素(TBIL)及非结合胆红素(IBIL)水平。比较三组新生儿血清TBA、TBIL及IBIL水平,分析其临床意义。结果生理性黄疸组和病理性黄疸组患儿血清TBA、TBIL和IBIL均明显高于对照组,差异均有统计学意义(P<0.05);病理性黄疸组患儿血清TBA、TBIL和IBIL明显高于生理性黄疸组,差异均有统计学意义(P<0.05)。结论 TBA和胆红素可以作为鉴别新生儿黄疸病因的重要实验室指标,值得在临床中推广应用。
Objective To investigate the changes of serum total bile acid (TBA) and bilirubin (BIL) in neonates with jaundice and its clinical significance. Methods A total of 120 neonates with jaundice, including 60 cases of physiological jaundice (physiological jaundice) and 52 cases of pathological jaundice (pathological jaundice), were selected as the control group. Serum TBA levels of three neonates were measured by the method of cyclic enzyme. The levels of total bilirubin (TBIL) and unconjugated bilirubin (IBIL) in neonates were measured by the method of vanadate oxidation. The levels of serum TBA, TBIL and IBIL in three groups were compared and their clinical significance was analyzed. Results The levels of serum TBA, TBIL and IBIL in children with physiological jaundice and pathological jaundice were significantly higher than those in control group (P <0.05). The levels of serum TBA, TBIL and IBIL in children with pathological jaundice were significantly higher than those in control group Higher than physiological jaundice, the difference was statistically significant (P <0.05). Conclusion TBA and bilirubin can be used as an important laboratory index to identify the etiology of neonatal jaundice and should be widely applied in clinical practice.