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目的:探讨初发高血压病患者血压昼夜节律变化与尿微量白蛋白的关系。方法:将186例初发原发性高血压病患者按照24h动态血压检测结果分为A、B两组:A组为杓形组,共71例;B组为非杓形组,共115例,分别检测血清超敏C反应蛋白和尿微量白蛋白水平。结果:B组的的超敏C反应蛋白水平明显高于A组[(6.97±13.17)mg/L与(2.34±1.49)mg/L(P<0.01)],B组的尿微量白蛋白水平明显高于A组[(21.08±3.97)μg/mL与(11.14±3.32)μg/mL,P<0.01](P<0.01)。结论:初发高血压病患者血压昼夜节律变化与炎症反应、尿微量白蛋白关系密切。
Objective: To investigate the relationship between circadian rhythm of blood pressure and urinary albumin in patients with essential hypertension. Methods: A total of 186 patients with primary essential hypertension were divided into A and B groups according to 24h ambulatory blood pressure test: group A was a dipper-shaped group with a total of 71 cases; group B was a non-dipper-shaped group with a total of 115 cases , Respectively, serum hs-CRP and urine microalbumin levels were detected. Results: The levels of hypersensitive C-reactive protein in group B were significantly higher than those in group A [(6.97 ± 13.17) mg / L vs (2.34 ± 1.49) mg / L, P <0.01] (21.08 ± 3.97) μg / mL and (11.14 ± 3.32) μg / mL, respectively, P <0.01] (P <0.01). Conclusion: The changes of circadian rhythm of blood pressure in patients with essential hypertension are closely related to inflammatory reaction and urine microalbumin.