论文部分内容阅读
目的 探讨18F-脱氧葡萄糖(18F-deoxyglucose,18F-FDG)正电子发射计算机断层(positron emission tomography-computed tomography, PET/CT)脑显像在致痫性I型局灶性脑皮层发育不良(TypeI focal cortical dysplasia, FCD-I)术前定位的价值.方法 回顾性总结癫痫病灶切除术后病理证实为FCD-I的19例患者临床资料.所有研究对像行18F-FDGPET/CT脑显像.首先定性分析(即视觉分析)19例患者18F-FDGPET/CT脑代谢减低表现,然后使用NeuroQ软件对18F-FDG PET/CT脑图像进行定量分析,并与病理结果比较.分析两种方法在致痫性FCD-I脑代谢显像术前定位中的准确率.结果 19例FCD-I型癫痫患者的PET/CT脑代谢图像定性分析显示,减低区均位于大脑皮层,其中12例(63.16%)表现为单部位代谢减低,7例(36.84%)表现为多部位代谢减低;19例癫痫患者的PET/CT图像定性分析结果与病理结果比较,14例患者(73.68%)的脑代谢减低区与病理结果一致,5例患者(26.32%)的脑代谢减低区为假阳性.19例FCD-I型癫痫患者的PET/CT脑代谢图像定量分析,均表现为多个部位代谢减低,其中主要代谢减低区与病理结果一致.联合两种分析方法,19例患者的脑代谢减低区均与病理结果一致.结论 18F-FDGPET/CT脑显像定性分析联合定量分析更加有助于癫痫灶的术前定位.“,”Objective To investigate the value of 18F-FDG PET/CT imaging in localization epileptogenic zone in presurgical evaluation of type I focal cortical dysplasia.Methods Preoperative 18F-FDG PET/CT imagings in 19 patients with epileptogenic type I focal cortical dysplasia confirmed by pathological results were retrospectively analyzed.The PET/CT images were qualitative visually assessed and quantitatively analyzed by NeuroQ software.All the results were compared with the pathology.Results The qualitative visually analysis found the FDG uptake decreased in single cerebral region of 12 patients, multiple cerebral regions in 7 patients.The qualitative analysis demonstrated FDG uptake decreased in multiple cerebral regions in 19 cases.The prominent regions of FDG uptake decreased were consistent with the pathological result.Conclusion The combination of PET-CT qualitative and quantitative analysis could increase the accuracy of epileptogenic focus localization in patients with type I focal cortical displasia.