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目的:观察对伴有抑郁症的FD(功能性消化不良)患者应用盐酸路优解进行治疗的临床效果与安全性。方法:对2008年5月—2011年5月于我院进行治疗的80例伴有抑郁症的FD患者临床资料进行回顾性分析。将其随机分为A、B两组,每组患者40例,对B组患者应用盐酸路优解与多潘立酮以及奥美拉唑进行联合治疗,对A组患者应用莫沙比利与路优泰进行联合治疗,两组均治疗4周,对两组临床症状的改善情况以及其不良反应的情况进行对比。结果:经4周治疗后,A组在缓解FD其症状方面以及治疗效果方面均优于B组,差异明显(P<0.01),并且没有出现任何不良反应。结论:对伴有抑郁症的FD患者合理加用盐酸路优解进行治疗,安全有效,应予临床推广。
OBJECTIVE: To observe the clinical effect and safety of the treatment of FD in patients with FD (functional dyspepsia) with depression. Methods: The clinical data of 80 FD patients with depression treated in our hospital from May 2008 to May 2011 were analyzed retrospectively. They were randomly divided into A, B two groups of 40 patients in each group, the B group of patients with hydrochloric acid Luoyu solution and domperidone and omeprazole for treatment, A group of patients with mosapride and Lu You Thai The patients in both groups were treated for 4 weeks. The improvement of clinical symptoms and the adverse reactions of the two groups were compared. Results: After 4 weeks of treatment, group A was superior to group B in alleviating the symptoms of FD and its therapeutic effect, with significant difference (P <0.01) and no adverse reaction. Conclusion: It is safe and effective to treat patients with FD accompanied by depression by reasonable addition of hydrocortisone hydrochloride. It should be clinically popularized.