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通过研究大鼠失血过程中口腔黏膜二氧化碳分压(PbuCO2)与失血性休克程度的相关性,证明PbuCO2可用于失血性休克早期救治过程中休克程度的评价.25只Wistar大鼠随机分成5组,用戊巴比妥钠麻醉后,除假手术组外,其余4组失血30min,失血量分别达到总血容量的25%,30%,35%和40%.用PbuCO2检测装置对大鼠口腔黏膜的PCO2进行连续、无创检测,并对动脉血压(ABP)、心输出量(CO)、心电(ECG)和呼吸(RES)进行实时或不间断的检测,另外不间断抽取动脉血进行血液检验.失血后30min时,除40%小组部分动物死亡外,其余存活动物的ABP,CO,ECG,RES,血气和电解质都没有显著差异,而仅失血15min后,相对上述生理指标,PbuCO2表现出极显著的差异性(P<0.01).实验证明,PbuCO2不仅能够检测失血后组织灌注的变化,而且与ABP,CO,血气和电解质等指标相比,在区分不同程度的休克时更具有一致性、准确性和灵敏性.结果显示,PbuCO2的连续无创检测可有效地评价失血性休克程度,指导早期救治.
By studying the correlation between PbuCO2 and hemorrhagic shock during the process of blood loss in rats, PbuCO2 can be used to evaluate the degree of shock in the early treatment of hemorrhagic shock.All 25 Wistar rats were randomly divided into 5 groups: After anesthesia with sodium pentobarbital, except the sham-operation group, the other 4 groups of blood loss for 30min, blood loss reached 25%, 30%, 35% and 40% of the total blood volume respectively.Using PbuCO2 detection device on rat oral mucosa Of PCO2 for continuous and noninvasive detection, and real-time or uninterrupted detection of arterial blood pressure (ABP), cardiac output (CO), electrocardiogram (ECG) and respiration (RES) At 30min after blood loss, there was no significant difference in ABP, CO, ECG, RES, blood gas and electrolytes in the remaining surviving animals except for 40% of the animals in the group, and only 15min after the blood loss, relative to the above physiological indexes, PbuCO2 showed extremely (P <0.01) .Pruc2 is not only able to detect the change of tissue perfusion after hemorrhage, but also consistent with different levels of shock compared with ABP, CO, blood gases and electrolytes, Accuracy and sensitivity.The results show that, Continuous non-invasive detection of PbuCO2 can effectively evaluate the degree of hemorrhagic shock and guide early treatment.