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采用放射免疫法检测４１例胃肠恶性肿瘤和２０名健康人血清癌胚肮原（ＣＥＡ），糖链抗原（ＣＡ１９－９、ＣＡ５０）含量，并与癌组织学分类、有无淋巴结转移对比分析。结果显示：胃肠肿瘤ＣＥＡ、ＣＡ１９－９、ＣＡ５０值明显高于对照组（Ｐ＜０．０１）。胃癌伴肝、胰转移时ＣＡ１９－９增高尤其显著，胃癌ＣＡ５０值高于大肠癌（Ｐ＜０．０５）。胃肠肿瘤淋巴结转移者三项指标检出率较无转移者高，但差异无显著性。病理分类中胃癌ＣＥＡ阳性率腺癌＞低分化腺癌，ＣＡ１９－９、ＣＡ５０为腺癌＞低分化腺癌＞粘液腺癌。大肠癌ＣＥＡ阳性率乳头状腺癌＞低分化腺癌＞管状腺癌，ＣＡ１９－９、ＣＡ５０为低分化腺癌＞管状腺癌＞乳头状腺癌。三项标志物联检在胃、大肠癌的阳性率为９５．０％和８５．７％。
Radioimmunoassay was used to detect the content of CEA and CA19-9, CA50 in 41 cases of gastrointestinal malignancies and 20 healthy individuals, and compared with histological classification and lymph node metastasis. . The results showed that: CEA, CA19-9, CA50 values of gastrointestinal tumors were significantly higher than the control group (P <0.01). The increase of CA19-9 was especially significant in gastric cancer with liver and pancreas metastasis, and the CA50 value of gastric cancer was higher than that of colorectal cancer (P<0.05). The detection rate of three indicators of lymph node metastasis of gastrointestinal tumors was higher than those without metastases, but the difference was not significant. The pathological classification of gastric cancer CEA positive rate adenocarcinoma> poorly differentiated adenocarcinoma, CA19-9, CA50 are adenocarcinoma> poorly differentiated adenocarcinoma> mucinous adenocarcinoma. Colorectal cancer CEA Positive rate Papillary adenocarcinoma> Poorly differentiated adenocarcinoma> Tubular adenocarcinoma, CA19-9, CA50 are poorly differentiated adenocarcinoma> Tubular adenocarcinoma> Papillary adenocarcinoma. The positive rate of the three markers in the stomach and colon cancer was 95.0% and 85.7%.