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目的短期胰岛素泵强化治疗对不同病程2型糖尿病的疗效及安全性分析。方法资料随机选自我院2013年1月至2014年2月2型糖尿病患者60例,按病程程度分为三组,A组(病程<2年)30例;B组(病程2~4年)15例,C组(病程>4年)15例,三组均使用短期胰岛素泵强化治疗,对患者治疗前后的临床资料进行回顾性分析。结果用药治疗14 d后,三组患者空腹时的血糖、餐后2 h血糖、三酰甘油以及糖化血红蛋白,均比用药前有显著下降,比较具有统计学意义(P<0.05);随着病程的延长,B、C组与A组相比,治疗效果逐渐下降,因此越早治疗效果越好。结论短期胰岛素泵强化治疗不同病程2型糖尿病能够使高血糖得到有效控制,并改善脂代谢,降低低血糖的发生率,药物安全性高,值得在临床中推广应用。
Objective To evaluate the efficacy and safety of short-term insulin pump in the treatment of type 2 diabetes mellitus with different course of disease. Method data were randomly selected from our hospital from January 2013 to February 2014 60 cases of type 2 diabetes mellitus, according to the degree of disease is divided into three groups, A group (duration <2 years) 30 cases; B group (duration 2-4 years) 15 cases, C group (duration> 4 years) 15 cases, three groups were treated with short-term insulin pump intensive treatment before and after treatment of patients with clinical data were retrospectively analyzed. Results After treatment for 14 days, the fasting blood glucose, postprandial 2-hour blood glucose, triglyceride and glycosylated hemoglobin in the three groups were significantly lower than those before treatment (P <0.05). With the course of disease Of the extension, B, C group compared with the A group, the therapeutic effect gradually decreased, so the sooner the better the treatment effect. Conclusion Short-term intensive insulin treatment of type 2 diabetes mellitus can effectively control hyperglycemia and improve lipid metabolism and reduce the incidence of hypoglycemia. It is safe and should be widely applied in clinical practice.