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目的:探讨钙剂加小剂量肠溶阿司匹林对妊娠期高血压疾病的疗效及可能的机制.方法:妊娠期高血压疾病的孕妇78例分为对照组和实验组各39例,前者仅用硫酸镁常规解痉降压,后者在解痉降压基础上口服多维钙咀嚼片(迪巧)及小剂量肠溶阿司匹林.观察两组母婴结局.平均动脉血压、24h尿蛋白和血清钙水平的改变,以及凝血和血栓前状态分子标志物水平的变化.结果:实验组和对照组胎心异常率依次为7.69%和23.08%,差异具有统计学意义(P<0.01).治疗前实验组平均动脉血压为(126.2±15.6)mmHg(1mmHg=0.133kPa),24h尿蛋白为(3.85±0.47)g和血清钙为(1.83±0.41)mmol/L,治疗后依次为(102.5±16.8)mmHg,(1.56±0.63)g和(2.44±0.35)mmol/L,差异具有统计学意义(P<0.01~0.05).实验组治疗前PT,Fbg,TAT和D-dimer检测值依次为(10.92±0.55)s,(5.8±1.3)g/L,(24.5±4.3)mg/L和(1.55±0.46)mg/L,治疗后依次为(11.26±0.82)s,(4.2±0.6)g/L,(9.56±3.7)mg/L和(0.72±0.22)mg/L,差异均具有统计学意义(P<0.01~0.05).结论:钙剂加小剂量肠溶阿司匹林治疗妊娠期高血压疾病效果较好,能有效降低平均动脉血压,改善患者孕妇凝血功能和血栓前状态,改善母婴结局.
Objective: To investigate the effect and possible mechanism of calcium and small dose enteric-coated aspirin on hypertensive disorder complicating pregnancy.Methods: 78 pregnant women with gestational hypertension were divided into control group and experimental group (39 cases each) Magnesium conventional antispasmodic and antihypertensive, the latter based on the antispasmodic antihypertensive oral multidimensional calcium chewable tablets (Di Qiao) and low-dose enteric-coated aspirin.Male and infant outcomes were observed in two groups.The mean arterial pressure, 24h urinary protein and serum calcium levels , And the changes of coagulation and prethrombotic state molecular markers.Results: The abnormal rate of fetal heart rate in experimental group and control group were 7.69% and 23.08% respectively, the difference was statistically significant (P <0.01) The average arterial blood pressure was (126.2 ± 15.6) mmHg (1mmHg = 0.133kPa), 24h urine protein was (3.85 ± 0.47) g and serum calcium was (1.83 ± 0.41) mmol / L and followed by (102.5 ± 16.8) mmHg , (1.56 ± 0.63) g and (2.44 ± 0.35) mmol / L respectively, the difference was statistically significant (P <0.01-0.05) .The PT, Fbg, TAT and D-dimer values before treatment in the experimental group were (10.92 ± (11.2 ± 0.82) s and (± 4.2 ± 0.6) g / L, respectively (P <0.05) , (9.56 ± 3.7) mg / L and (0.72 ± 0.22) mg / L, respectively (all P <0.01 ~ 0.05) .Conclusion: Calcium and low-dose enteric-coated aspirin are effective in treating hypertensive disorder complicating pregnancy.It can effectively reduce the average arterial pressure, Improve the coagulation function and prothrombotic state in pregnant women and improve maternal and infant outcomes.