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目的探讨新生儿缺氧缺血性脑病的临床诊治措施。方法回顾分析76例患儿的临床资料。结果治疗组38例患儿中,经治疗显效33例,有效4例,无效1例;对照组38例中,经治疗显效16例,有效16例,无效6例。两组患儿有效率相比差异有统计学意义P<0.05。结论一般对于诊断明确的新生儿缺氧缺血性脑病应用纳洛酮治疗是越早用越好,这样可增强脑细胞抗缺氧能力,控制脑水肿的进一步发展,缩短病程提高治愈率,减少患者后遗症的发生;纳洛酮属于剂量依赖性药物,临床应用纳洛酮的剂量并无明确标准,一般认为在一定范围内,剂量越大效果就越好。
Objective To investigate the clinical diagnosis and treatment of neonatal hypoxic-ischemic encephalopathy. Methods The clinical data of 76 children were retrospectively analyzed. Results 38 cases of treatment group, the treatment of 33 cases markedly effective in 4 cases, 1 case of ineffective; control group of 38 cases, the treatment was effective in 16 cases, effective in 16 cases, 6 cases. The difference between the two groups was statistically significant (P <0.05). CONCLUSIONS: The earlier the naloxone treatment is applied, the better the treatment of neonatal hypoxic-ischemic encephalopathy is diagnosed, the better the anti-hypoxic ability of brain cells can be enhanced, the further development of cerebral edema can be controlled, the duration of treatment can be shortened, the cure rate can be increased, Naloxone is a dose-dependent drug, there is no clear standard for the dosage of naloxone in clinical practice, and it is generally believed that the greater the dosage, the better the effect will be in a certain range.