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目的观察新生儿缺氧缺血性脑病(hypoxic-ischemic encephalopathy,HIE)应用川芎嗪治疗后血清总钙、一氧化氮、肿瘤坏死因子-α及脑型肌酸激酶同工酶水平的变化,探讨川芎嗪治疗新生儿HIE的机制。方法 82例HIE患儿随机分为川芎嗪组和对照组各41例,对照组给予吸氧、降低颅内压、控制惊厥、促进脑细胞代谢、纠正水电解质和酸碱平衡紊乱等常规治疗,川芎嗪组在对照组治疗基础上给予川芎嗪注射液2～4mg/(kg.d),静脉滴注,1次/d,2组均治疗10d。分别于治疗前,治疗第8天测定2组血清总钙、一氧化氮、肿瘤坏死因子-α及脑型肌酸激酶同工酶水平并进行比较。结果川芎嗪组治疗第8天血清总钙均较治疗前及对照组增高(P<0.05),血清一氧化氮、肿瘤坏死因子-α、脑型肌酸激酶同工酶水平较治疗前及对照组降低(P<0.05)。结论川芎嗪可减轻HIE新生儿的脑损伤。
Objective To observe the changes of serum total calcium, nitric oxide, tumor necrosis factor-α and brain-type creatine kinase isoenzyme after the treatment of ligustrazine in neonatal hypoxic-ischemic encephalopathy (HIE) Mechanism of tetramethylpyrazine in neonatal HIE. Methods Eighty-two children with HIE were randomly divided into four groups: the Ligustrazine group and the control group, 41 cases in each group. The control group was given oxygen, decreased intracranial pressure, controlled seizure, promoted brain cell metabolism, corrected routine treatment such as water, electrolyte and acid- Ligustrazine group was given Ligustrazine Injection 2 ~ 4mg / (kg.d) on the basis of the control group, intravenous drip, once / d, and the two groups were treated for 10 days. The levels of serum total calcium, nitric oxide, tumor necrosis factor-α and brain-type creatine kinase were measured before treatment and on the 8th day of treatment respectively. Results The serum total calcium in the ligustrazine group on the 8th day was higher than that before treatment and in the control group (P <0.05). The levels of serum nitric oxide, tumor necrosis factor-α and cerebral creatine kinase were higher than those before treatment and before treatment Group decreased (P <0.05). Conclusion Tetramethylpyrazine can reduce brain injury in neonates with HIE.