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利凡诺(雷佛奴尔)水溶液不稳定,遇光易变成褐色,故水针剂不能久贮。为保证药品质量,将其制成粉针剂以利稳定。自1977年以来,我院制备的利凡诺粉针剂,用于中期妊娠引产1,130例,其中经产妇的成功率为98.3%,初产妇为98.5%,未发现不良反应。一、制备方法市售利凡诺为供外用的原料,作为注射引产用,须经精制处理,以除去杂质。 1.精制方法:取利凡诺粉末25～30克(系吉林省辽源市制药三厂生产)置于清洁干燥的容器内,加无水乙醇500毫升,于70℃水浴中加热搅拌溶解,趁热抽滤,滤液密封,
Richeno (Raynaud) aqueous solution is unstable, in the case of light easily become brown, so water injection can not be long storage. In order to ensure the quality of medicines, it is made into powder for ease of stability. Since 1977, our hospital prepared rivanol injections for mid-term pregnancy induced labor 1,130 cases, of which the success rate of 98.3% of mothers, primipara was 98.5%, no adverse reactions were found. First, the preparation method Commercial rivanol for external use of raw materials, as the injection of induction of labor, to be refined to remove impurities. 1. Refining method: take Richerino powder 25 to 30 grams (Department of Liaoyuan City, Jilin Province Pharmaceutical Factory production) placed in a clean dry container, add 500 ml of absolute ethanol, heated in a 70 ° C water bath to dissolve, take advantage of Hot suction filtration, filtrate seal,