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检测并比较了ＨＬＡＩ类抗原（ＨＬＡ－Ａ、Ｂ位点）在２５例中国汉人典型骨肉瘤患者及２５０例健康汉人的表达频率，发现ＨＬＡ－Ｂ３５抗原在骨肉瘤组频率为０．４０，对照组为０．０４８，统计显示携带ＨＬＡ－Ｂ３５抗原的中国汉人骨肉瘤发病的相对风险率是不带此抗原者的１３．２２°倍（Ｐ＜０．０１）。此外，ＨＬＡ－Ｂ１３与骨肉瘤患者的不良预后相关，其相对风险率为１２．０４８倍（Ｐ＜０．０５），同时携带ＨＬＡ－Ｂ１３与ＨＬＡ－Ｂ３５抗原的患者，更表现出预后差的趋势。
The frequency of expression of HLA class I antigens (HLA-A, B sites) in 25 Chinese classical osteosarcoma patients and 250 healthy Hans was detected and compared. The frequency of HLA-B35 antigen in osteosarcoma group was 0.40. The group was 0.048. The statistics showed that the relative risk of osteosarcoma in Chinese Han people with HLA-B35 antigen was 13.22 times (P<0.01). In addition, HLA-B13 was associated with a poor prognosis in osteosarcoma patients, with a relative risk rate of 12.048-fold (P<0.05). Patients with HLA-B13 and HLA-B35 antigens also showed poor prognosis. trend.