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p16INK4a基因是一种抑癌基因,在CyclinD-CDK4/6-pRb-E2F通路中发挥重要负反馈调节作用,大部分恶性肿瘤中均发现该基因表达缺失。p16INK4a低表达是卵巢癌不利的预后指数,可作为卵巢癌独立的预后因子;p16INK4a在宫颈癌中呈过表达,有助于宫颈癌的筛查;p16INK4a在子宫内膜癌发生发展中起着重要作用,与子宫内膜癌转移灶发生率的增加密切相关;而在外阴癌HPV感染型中,常有p16INK4a过表达,是可靠的HPV阳性外阴癌的标记物。
The p16INK4a gene is a tumor suppressor gene that plays an important negative feedback regulation in CyclinD-CDK4 / 6-pRb-E2F pathway. The gene expression is found in most malignant tumors. Low expression of p16INK4a is a negative prognostic factor of ovarian cancer, which can be used as an independent prognostic factor for ovarian cancer. p16INK4a is overexpressed in cervical cancer and is helpful for screening of cervical cancer. p16INK4a plays an important role in the development of endometrial cancer Role, and the incidence of endometrial cancer metastases is closely related to the increase; and in vulvar cancer HPV infection, p16INK4a often overexpression, is a reliable marker of HPV-positive vulvar cancer.