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目的:探讨肿瘤堆积物(TDs)对胃癌根治术后患者预后的影响。方法:选取6年间行胃癌根治术患者100例,对其术后胃癌切除标本进行病理检查,分析TDs与患者肿瘤病理特征的关系,并结合随访资料行生存分析。结果:18例(18.0%)患者标本呈TDs阳性。与TDs阴性患者比较,TDs阳性患者肿瘤体积大[(5.62±2.48)cm vs.(4.83±2.17)cm];低分化癌比例高(66.7%vs.51.2%);淋巴结转移个数多[(9.2±8.4)个vs.(5.3±7.5)个];III期胃癌比例高(88.9%vs.36.6%);生存率降低(27.8%vs.56.3%),差异均有统计学意义(均P<0.001)。结论:TDs可作为判断胃癌根治术后患者预后的指标,阳性者预后差。
Objective: To investigate the effect of tumor deposits (TDs) on the prognosis of patients with gastric cancer after radical operation. Methods: A total of 100 patients underwent radical gastrectomy over 6 years were selected. Pathological examination was performed on the specimens of resected gastric cancer. The relationship between the TDs and the pathological features of the patients was analyzed. Survival analysis was performed based on the follow-up data. Results: Twenty-eight patients (18.0%) were positive for TDs. Compared with TDs-negative patients, TDs-positive patients had larger tumor volume [(5.62 ± 2.48) cm vs. (4.83 ± 2.17) cm], poorly differentiated carcinoma (66.7% vs.51.2%), more lymph node metastasis 9.2 ± 8.4) vs (5.3 ± 7.5), respectively; the proportion of stage III gastric cancer was high (88.9% vs.36.6%); the survival rate was lower (27.8% vs.56.3%), the differences were statistically significant <0.001). Conclusion: TDs can be used as an indicator of prognosis of patients with gastric cancer after radical operation, the positive prognosis is poor.