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探讨药物流产（药流）后出血延长患者血一氧化氮（ Ｎ Ｏ）和环磷酸鸟苷（ｃ Ｇ Ｍ Ｐ）的变化及中药宫复合剂对药流后阴道流血延长的防治作用。对 １２０ 例自愿接受药流的早孕妇女，随机分为 Ａ、 Ｂ 两组，于口服米非司酮前、后及药流后 １０ 天，分别测血 Ｎ Ｏ 和 ｃ Ｇ Ｍ Ｐ。 Ａ 组药流后服宫复合剂 ７ 天， Ｂ 组药流后７ 天内未予中药治疗。分别于药流后 １０、２０、３０ 及 ４０ 天随诊。结果： Ａ、 Ｂ 两组口服米非司酮后，血清 Ｎ Ｏ和血浆 ｃ Ｇ Ｍ Ｐ 显著下降（ Ｐ＜ ０．０５）。药流后 １０ 天， Ａ 组阴道流血终止例数明显多于 Ｂ 组（ Ｐ＜ ０．０５）。 Ａ组药流后 １０ 天血清 Ｎ Ｏ 和血浆 ｃ Ｇ Ｍ Ｐ均值显著低于 Ｂ 组（ Ｐ＜ ０．０５）。提示：药流后血 Ｎ Ｏ 和 ｃ Ｇ Ｍ Ｐ 浓度下降缓慢与药流后出血延长关系密切，中药宫复合剂对药流后出血延长有一定的防治作用。
To investigate the changes of blood nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) in patients with prolonged bleeding after medical abortion (drug abortion) and the preventive and therapeutic effects of Gongfanggui compound on vaginal bleeding after medical abortion. A total of 120 early pregnant women who voluntarily received medical abortion were randomly divided into A and B groups. Before and after oral administration of mifepristone, and 10 days after drug flow, blood levels of N O and cGMP were measured respectively. Group A drug abortion Gongfu compound for 7 days, group B drug abortion within 7 days without Chinese medicine treatment. Respectively 10, 20, 30 and 40 days after medical abortion. Results: After oral administration of mifepristone, the levels of serum NO and plasma cGMP decreased significantly in groups A and B (P <0.05). 10 days after drug abortion, A group of vaginal bleeding was significantly more cases than the B group (P <0.05). The mean of serum NO and plasma cGMP in group A at 10 days after drug abdication was significantly lower than that in group B (P <0.05). It is suggested that the decrease of N0 and cGMP concentrations in bloodstream after drug abstention rate is closely related to the prolongation of bleeding after abortion, and the Chinese medicine Gongcai compound has some preventive and therapeutic effects on prolongation of abortion.