关于大蒜和大蒜素质量标准的商榷

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国家药品标准W S-10001-(HD-0050)-2002中规定大蒜素为三硫二丙烯,本文对大蒜中含硫有机化合物的转化途径及药理作用进行综述,说明大蒜素与大蒜虽然名称相似,但并非大蒜中的天然成分,而是蒜氨酸与蒜酶接触降解出的含硫有机化合物,后改由合成得到,因此在中国药典2010年版一部收载的大蒜药材标准中测定三硫二丙烯含量应进行修订。目前国内合成的大蒜素为丙烯基多硫化物的混合物,建议对其质量标准进行修订并取消大蒜素该名称,改为直接采用化学名称三硫二丙烯进行命名。大蒜中很多含硫有机化合物的命名混乱,造成文献中的研究成果无法准确表述,建议对大蒜中含硫有机化合物的命名进行规范。 The national drug standard W S-10001- (HD-0050) -2002 stipulates that allicin is trithiopropylene. In this paper, the transformation pathways and pharmacological effects of sulfur-containing organic compounds in garlic are reviewed. Although the names of allicin and garlic are similar , But not the natural ingredients of garlic, but alliin and garlic enzyme degradation of the sulfur-containing organic compounds, after the change obtained from the synthesis, so in the Chinese Pharmacopoeia 2010 edition of a collection of garlic herbs standard trisulfide Propylene content should be revised. At present, the domestic synthesis of allicin is a mixture of propylene-based polysulfides, it is proposed to amend its quality standards and cancel the allicin the name changed to the direct use of chemical name trithiopropylene naming. Garlic in the name of many chaos of sulfur-containing organic compounds, resulting in the literature can not accurately describe the research results, it is recommended garlic nomenclature of sulfur-containing organic compounds specification.
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