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目的 :研究当地饮酒习惯与乙醛脱氢酶 2 (ALDH2 )基因的多态性对肝癌危险性的影响。方法 :在江苏泰兴市选择 1999年 9月 1日～ 2 0 0 0年 12月 31日新发肝癌病人 88例 ,按性别、年龄和居住地1∶1配对 ,进行流行病学调查研究 ,并应用PCR RFLP方法检测研究对象的ALDH2基因型。统计分析采用EpiInfo软件包。结果 :饮大量高度酒能显著增加ALDH2变异基因型携带者患肝癌的危险性 (OR=7 2 0 ,χ2 =6 6 5 ,P <0 0 1)。结论 :ALDH2基因多态性和饮酒习惯与肝癌的发生有关。
Objective: To study the influence of local drinking habits and the ALDH2 gene polymorphism on the risk of liver cancer. Methods: 88 cases of newly diagnosed hepatocellular carcinoma patients were recruited in Taixing, Jiangsu Province from September 1, 1999 to December 31, 2000. Their epidemiological investigation was conducted according to sex, age and place of residence 1: 1 The PCR RFLP method was used to detect the ALDH2 genotype of the study subjects. Statistical analysis using EpiInfo package. Results: Drinking a large amount of high alcohol could significantly increase the risk of liver cancer in ALDH2 variant genotype carriers (OR = 7 20, 2 = 665, P <0.01). Conclusion: ALDH2 gene polymorphism and drinking habits are related to the occurrence of liver cancer.