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目的:观察活血通络汤对急性血瘀模型大鼠血液流变学及体外血栓形成各项指标的影响。方法:采用皮下注射盐酸肾上腺素复加冰水浴造成大鼠急性血瘀模型,观察活血通络汤对急性血瘀模型大鼠血液流变学指标、血小板聚集及体外血栓形成影响。结果:活血通络汤能延长急性血瘀模型大鼠APTT、TT、PT,抗血小板聚集,降低血液黏度及血栓干湿重,药效同复方丹参片组相当,且作用呈剂量依赖性,其中活血通络汤高、中剂量组与模型组之间的比较具有显著性差异(P<0.05或P<0.01),而与正常对照组比较无显著性差异(P(0.05),提示其作用的安全有效性。结论:活血通络汤能改善血液流变学指标、抗血小板聚集及体外血栓形成,对髋关节术后下肢深静脉血栓形成有防治作用。
Objective: To observe the effect of Huoxuetongluo decoction on hemorrheology and extracorporeal thrombosis in acute blood stasis model rats. Methods: Acute blood stasis model was induced by subcutaneous injection of epinephrine hydrochloride and ice water bath in rats. The effects of Huoxuetongluo Decoction on hemorrheological parameters, platelet aggregation and thrombus formation in vitro were observed. Results: Huoxue Tongluo Decoction can prolong APTT, TT, PT, anti-platelet aggregation, reduce blood viscosity and thrombus wet-dry weight in acute blood stasis model rats. The drug efficacy is equivalent to that of Fufang Danshen Tablets, and the effect is dose- Huoxuetongluo Decoction high, medium dose group and the model group was significantly different (P <0.05 or P <0.01), while compared with the normal control group no significant difference (P (0.05), suggesting that the role of Safe and effective.Conclusion: Huoxue Tongluo Decoction can improve the indexes of hemorrheology, anti-platelet aggregation and thrombosis in vitro, and has the preventive and therapeutic effects on deep venous thrombosis of lower extremities after hip surgery.