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癫痫患者脑组织标本及癫痫动物模型研究发现,多种神经递质与癫痫有关。通过向体内引入这些神经递质不同受体亚型的特异性放射性配体,可以得到脑内受体分布图,反映它们在癫痫发生中的作用,同时检测出癫痫灶,这也就是癫痫的PET受体显像原理。较之于传统的癫痫检查方法,PET受体显像的特异性和敏感性都极高,可以检测出MRI、CT阴性的癫痫灶,具有很高的临床诊断价值,而且为研究癫痫的发病机制、抗痫药物及抗痫疗效评估提供了一种很好的无创伤性手段,从而为难治性癫痫的最终攻克带来希望。
Epilepsy patients with brain tissue samples and animal models of epilepsy study found that a variety of neurotransmitters and epilepsy. By introducing these specific radioligands of these neurotransmitters to different receptor subtypes in vivo, a map of intracerebral receptors can be obtained reflecting their role in epileptogenesis and detecting epileptic foci, which is also known as epileptic PET Receptor imaging principle. Compared with traditional methods of detecting epilepsy, PET receptor imaging has high specificity and sensitivity, can detect MRI, CT-negative epileptic foci, has a high clinical diagnostic value, but also to study the pathogenesis of epilepsy , Anti-epileptic drugs and evaluation of the efficacy of anti-epilepsy provides a very good non-invasive means to eventually hope for the treatment of intractable epilepsy.