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目的:观察和分析甲亢患者采用稳心颗粒联合甲巯咪唑片治疗临床疗效。方法:按照随机数字表将2012年1月—2014年4月所收治的65例甲亢患者分组为对照组和观察组。对照组:采用西药甲巯咪唑片治疗,观察组:采用稳心颗粒联合甲巯咪唑片治疗。观察两组患者临床疗效和不良反应及治疗前后血清FT3、FT4、TSH情况。结果:治疗前,观察组患者FT3为(18.27±9.75)pmol/L、FT4为(51.01±34.37)pmol/L、TSH为(0.07±0.08)u IU/ml与对照组FT3为(17.86±9.86)pmol/L、FT4为(50.96±34.61)pmol/L、TSH为(0.06±0.07)u IU/ml比较(P>0.05);治疗后,观察组患者FT3、FT4、TSH分别为(8.07±1.91)pmol/L、(19.87±6.51)pmol/L、(0.98±1.65)u IU/ml与对照组(11.01±1.75)pmol/L、(26.12±7.15)pmol/L、(0.51±0.57)u IU/ml比较(P<0.05)。观察组治疗有效率和不良反应率分别为90.91%(30/33)、3.03%(1/33)与对照组81.25%(26/32)、15.63%(5/32)比较(P<0.05)。结论:甲亢患者采用稳心颗粒联合西药甲巯咪唑片治疗,其有效改善患者血清甲状腺激素水平,提高临床疗效,且不良反应少,值得推广与应用。
Objective: To observe and analyze the clinical effect of Wenxin granule combined with methimazole tablets in patients with hyperthyroidism. Methods: According to the random number table, 65 patients with hyperthyroidism admitted from January 2012 to April 2014 were divided into control group and observation group. Control group: Western medicine methimazole tablets treatment group: observation group: Wenxin particles combined with methimazole tablets treatment. The clinical efficacy and adverse reactions of the two groups were observed and the serum levels of FT3, FT4 and TSH were measured before and after treatment. Results: Before treatment, the FT3 in the observation group was (18.27 ± 9.75) pmol / L, the FT4 was (51.01 ± 34.37) pmol / L, the TSH was 0.07 ± 0.08 uU / ml and the control group FT3 was (17.86 ± 9.86) (P <0.05). After treatment, the FT3, FT4 and TSH in the observation group were (8.07 ± 0.06) μmol / L and (1.91) pmol / L, (19.87 ± 6.51) pmol / L, (0.98 ± 1.65) u IU / ml and control group (11.01 ± 1.75) pmol / u IU / ml (P <0.05). The effective rate and adverse reaction rate in the observation group were 90.91% (30/33), 3.03% (1/33) and 81.25% (26/32) respectively in the observation group and 15.63% (5/32) in the observation group (P <0.05) . Conclusion: The patients with hyperthyroidism treated with Wenxinkeli and western medicine methimazole tablets can effectively improve the level of serum thyroid hormone, improve the clinical curative effect, and have fewer adverse reactions, which deserves promotion and application.