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1 瘦素的结构 瘦素 (leptin)是肥胖相关基因 (ob)编码分泌性蛋白质 ,小鼠ob基因由Zhang等在 1 994年从遗传性肥胖小鼠 (ob)的脂肪组织中首次克隆[1 ] ,此后 ,Isse等成功克隆了人的肥胖基因(位于 7q32 )。瘦素主要由白色脂肪组织产生、分泌 ,棕色脂肪、骨骼肌、骨膜、胎盘、
1 Structure of leptin Leptin is a gene encoding a secreted protein associated with the ob gene. The mouse ob gene was first cloned from adipose tissue of obese obese mice (ob) by Zhang et al. In 1994 [1 Since then, Isse et al successfully cloned a human obesity gene (located at 7q32). Leptin is mainly produced by white adipose tissue, secreted, brown fat, skeletal muscle, periosteum, placenta,