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目的 探讨SARS患者肝功能损害特点及药物对肝功能的影响。方法 2 2 2例确诊患者分为普通型和重型。每型患者依ALT值分为正常、轻、中、重度组进行比较。将甘草酸单胺与谷胱甘肽分成单独治疗组和协同治疗组 ,观察其疗效。将应用头孢三代药物治疗的重型患者分别进行治疗前后肝功能测定值的比较 ,并同未应用头孢三代药物的重型患者肝功能损坏相比较。结果 2 2 2例SARS患者肝功能总损害率为 6 1.7% ,其中轻度占35 .4 % ,中度占 2 1.7% ,重度占 4 .5 % ;重型患者发生肝损害比例与程度高于普通型。三组药物观察 ,治疗前后差别显著。应用头孢三代治疗者治疗后肝功能损害程度增加 ,与未应用头孢三代治疗的重型患者肝功能损坏比较 ,差异不显著。结论 SARS患者肝脏损害较重 ,重型患者发生比例与程度高于普通型。头孢三代药物可增加肝损害程度。
Objective To investigate the characteristics of liver damage in patients with SARS and the effects of drugs on liver function. Methods Twenty-two patients diagnosed were divided into normal type and heavy type. Each type of patients according to the ALT value is divided into normal, mild, moderate and severe groups were compared. Glycyrrhizin monoamine and glutathione were divided into treatment group and treatment group, to observe its curative effect. The application of cephalosporins three generations of drug treatment of heavy patients were measured before and after treatment of liver function values ?? were compared with those who did not use cephalosporin drugs in patients with severe liver damage compared. Results The total damage rate of liver function in 2 2 SARS patients was 61.7%, of which mild was 35.4%, moderate was 2 1.7% and severe was 4.5%. The proportion and degree of liver damage in severe patients were higher than those in severe cases normal type. Three groups of drugs observed before and after treatment significantly different. The application of ceftriaxone treatment increased the degree of liver damage, compared with the non-application of ceftriaxone treatment of patients with severe liver damage, the difference was not significant. Conclusion The patients with SARS suffered severe damage to the liver, and the proportion and severity of severe cases were higher than those of common type. Three generations of cephalosporins can increase the degree of liver damage.