目的　探讨基质金属蛋白酶 2 (MMP 2 )、基质金属蛋白酶 9(MMP 9)和金属蛋白酶抑制因子 (TIMP 1)与结直肠癌术后肝转移的关系 ,评价其在预测结直肠癌肝转移中的作用。方法　 1997年 1～ 12月行结直肠癌根治术 59例 ,将组织石蜡块切片后 ,分别采用MMP 2、MMP 9和TIMP 1鼠单克隆抗体进行免疫组化染色。结果　结直肠癌术后肝转移率为 2 7 1%。转移组与未转移组MMP 9和TIMP 1两者相比差异有极显著意义 (P <0 0 0 1)。结论　对于预测结直肠癌手术后肝脏转移 ,MMP 9和TIMP 1有一定的价值 ,而三者联合应用可以提高诊断的灵敏度和特异度 Objective To investigate the relationship between the expression of matrix metalloproteinase 2 (MMP 2), matrix metalloproteinase 9 (MMP 9) and metalloproteinase inhibitor (TIMP 1) and postoperative liver metastases in colorectal cancer and to evaluate their correlation with the prediction of liver metastases in colorectal cancer effect. Methods 59 cases of colorectal cancer radical mastectomy were performed from January 1997 to December 1997. The tissue paraffin blocks were sliced ​​and then immunohistochemically stained with monoclonal antibodies to MMP 2, MMP 9 and TIMP 1 respectively. Results Colorectal cancer postoperative liver metastasis rate was 27.1%. There was significant difference between MMP 9 and TIMP 1 in metastasis group and non-metastasis group (P <0.01). Conclusions MMP 9 and TIMP-1 are of value in predicting liver metastases after colorectal cancer surgery, and the combination of the three can improve the sensitivity and specificity of the diagnosis