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目的 观察IMVP16方案作为难治性非霍奇金淋巴瘤的抢救性治疗方案的疗效及毒性。方法 采用IMVP16(IFO、MTX、VP16)方案治疗30例复治或CHOP、BEPP方案治疗无效的NHL,本组化疗均达到2个或2个以上周期。结果 30例中CR12例,占40%,PR18例,占60%,一例胃浸润者达到病理缓解。主要毒性反应为骨髓抑制、口腔炎、脱发及消化道反应,骨髓抑制Ⅲ～Ⅳ度占467%,口腔炎发生率较高占30%,脱发Ⅰ～Ⅲ度分别为135%、20%、333%,消化道反应多数为Ⅰ～Ⅱ度,占867%。未出现明显肝肾毒性,无一例发生中枢神经系统毒性及出血性膀胱炎。结论 IMVP16方案可作为难治性NHL的抢救治疗方案,安全、有效。
Objective To observe the efficacy and toxicity of IMVP16 regimen as a salvage treatment for refractory non-Hodgkin’s lymphoma. Methods 30 cases of retreatment or CHOP and BEPP regimen were treated with IMVP16 (IFO, MTX, VP16) regimen to treat ineffective NHL. The chemotherapy in this group reached 2 or more cycles. Results 30 cases of CR12 cases, 40%, PR18 cases, accounting for 60%, a case of stomach infiltration pathological remission. The main toxicity was myelosuppression, stomatitis, alopecia and digestive tract reaction. The myelosuppression accounted for 467% Ⅲ ~ Ⅳ, the high incidence of stomatitis 30%, and the degree Ⅲ ~ Ⅲ of alopecia were 135%, 20%, 333 %, The majority of gastrointestinal reactions Ⅰ ~ Ⅱ degrees, accounting for 867%. No obvious liver and kidney toxicity, no case of central nervous system toxicity and hemorrhagic cystitis occurred. Conclusion IMVP16 regimen can be used as a rescue treatment for refractory NHL, which is safe and effective.