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本研究以小鼠骨髓细胞微核率为指标，观察中医补血代表方剂四物汤抗环磷酰胺诱导突变的作用。结果表明：四物汤能明显抑制环磷酰胺所致小鼠骨髓细微核胞率的增高（Ｐ＜０．０１），提示四物汤具有良好的抗突变作用。
In this study, the micronucleus rate of mouse bone marrow cells as an indicator to observe the effect of traditional Chinese medicine on behalf of the four drugs Decoction Cyclophosphamide induced mutation. The results showed that Si Decoction can significantly inhibit the increase of bone marrow micronuclei in mice induced by cyclophosphamide (P <0.01), suggesting that Siwu Tang has a good anti-mutagenic effect.