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治疗头颈部鳞状细胞癌(HNSCC)的手段尽管不断改善,患者生活质量水平有所提高,但患者术后5年生存率并没有得到明显提高。治疗抵抗和复发一直是头颈鳞癌治疗中的难题,但局部组织内缺氧造成的乏氧微环境与肿瘤治疗抵抗和复发的关系密不可分。如果能采取有效措施改善肿瘤微环境乏氧状况,就可能提高HNSCC的治疗效果。
Despite improvements in the quality of life of patients with head and neck squamous cell carcinoma (HNSCC), the 5-year postoperative survival rate has not been significantly improved. The treatment of resistance and recurrence has been a challenge in the treatment of head and neck squamous cell carcinoma, but the hypoxic microenvironment caused by hypoxia in local tissues is closely related to the relapse and relapse of tumor therapy. If we can take effective measures to improve the hypoxic condition of the tumor microenvironment, it may improve the therapeutic effect of HNSCC.