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目的对α-2b干扰素联合膦甲酸钠抗乙肝病毒的疗效观察。方法选择慢性乙肝患者90例,随机分为两组,两组均用α-2b干扰素(安福隆)500万U1次/d肌肉注射,30d后改为隔日1次,总疗程为24周;均口服护肝药(甘草酸二铵肠溶胶囊)治疗。A组:用干扰素联合膦甲酸钠2.4g,静脉点滴,2次/d,疗程28d,和口服护肝药。B组:单用干扰素并口服护肝药。观察两组患者HBeAg、HBV-DNA的变化。结果治疗12周和24周时,A组HBeAg、HBV-DNA治疗有效率,都高于B组(P<0.05)。结论在干扰素进行乙肝抗病毒过程中,联用膦甲酸钠抗病毒治疗效果更好。
Objective To observe the effect of interferon alfa-2b and foscarnet against hepatitis B virus. Methods Ninety patients with chronic hepatitis B were randomly divided into two groups. The two groups were intramuscularly injected with interferon - α 2b (An Fulong) 5 times a day, once every other day for 30 days, and the course of treatment was 24 weeks. Oral liver medicine (diammonium glycyrrhizinate enteric-coated capsules) treatment. Group A: with interferon combined with foscarnet sodium 2.4g, intravenous drip, 2 times / d, treatment 28d, and oral Hugan drug. Group B: interferon alone and oral administration of liver medicine. The changes of HBeAg and HBV-DNA in two groups were observed. Results At 12 weeks and 24 weeks, the effective rate of HBeAg and HBV-DNA treatment in group A was higher than that in group B (P <0.05). Conclusions In the process of interferon for hepatitis B virus antiviral therapy combined with foscarnet is better.