论文部分内容阅读
目的:观察山莨菪碱(654-2)B6减少阿奇霉素胃肠道不良反应的效果。方法采用随机对照研究,对照组单纯使用阿奇霉素0.1—0.5g/qd静脉滴注。观察组加用山莨菪碱注射液1—5mg/qd观察两组胃肠道不良反应发生率。结果:对照组阿奇霉素出现呕吐不良反应率为72.9%,出现腹泻不良反应率为62.5%。加用山莨菪碱观察组出现呕吐、腹痛不良反应率为21.4%,出现腹泻、稀便不良反应率为42.9%。两组不良反应比较差异有高度统计学意义(P<0.01)。结论:山莨菪碱能减少或控制阿奇霉素胃肠道不良反应。
Objective: To observe the effect of anisodamine (654-2) B6 in reducing the side effects of azithromycin in gastrointestinal tract. Methods Randomized controlled study, the control group simply with azithromycin 0.1-0.5g / qd intravenous infusion. The observation group plus anisodamine injection 1-5mg / qd observed the incidence of gastrointestinal adverse reactions in both groups. Results: In the control group, the adverse reaction rate of vomiting in azithromycin was 72.9% and the rate of adverse reaction to diarrhea was 62.5%. Addition of anisodamine observation group vomiting, abdominal adverse reaction rate was 21.4%, diarrhea, loose stools adverse reaction rate was 42.9%. There was a statistically significant difference in adverse reactions between the two groups (P <0.01). Conclusion: Anisodamine can reduce or control azithromycin gastrointestinal adverse reactions.