自Moore(1965)首次发现S-100蛋白之后,人们起初一直认为这种酸性蛋白是神经组织特异性的。近来,不少研究证实:S-100蛋白可作为表皮或粘膜内郎格罕氏细胞(Langerhans cell LC)的免疫组化标记物。骨嗜酸性肉芽肿、韩—薛—柯氏病(H-S-C氏病)和勒雪氏病(L-S氏病)是一类具有相关的临床和组织学表现的综合征, Lichtenstein (1953)将这三种病总称为组织细胞增生症X(histiocytosisX,HX)。HX的主要病变细胞为15～25 After the first discovery of S-100 protein by Moore (1965), people initially considered this acidic protein to be neural tissue-specific. Recently, many studies have confirmed that S-100 protein can be used as an immunohistochemical marker for Langerhans cell LC in the epidermis or mucosa. Eosinophilic granuloma, Han-Schow-Coach disease (HSC’s disease) and Lechers disease (LS’s disease) are a class of syndromes with associated clinical and histological manifestations, Lichtenstein (1953) The disease is collectively referred to as histiocytosis X (HX). HX’s main diseased cells are 15-25