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目的探讨透明质酸介导的细胞游走受体(RHAMM)以及Xklp2靶蛋白(TPX2)蛋白在卵巢上皮性癌中的表达及其与临床病理特征的关系。方法应用免疫组化EnVision二步法检测51例卵巢上皮性癌(A组)、20例上皮性卵巢交界性肿瘤(B组)、22例上皮性卵巢良性肿瘤(C组)以及12例正常卵巢组织(D组)中RHAMM和TPX2蛋白的表达。结果 RHAMM与TPX2蛋白在D组均不表达;在C组、B组和A组中阳性表达率分别为22.7%和9.1%、30.0%和55.0%、88.2%和86.3%,组间差异均有统计学意义(P<0.01)。A组中RHAMM蛋白表达与病理分期、淋巴结转移相关(P<0.05),而与年龄、病理类型、组织分级无关(P>0.05);TPX2蛋白表达与病理分期、组织分级、淋巴结转移相关(P<0.05),而与年龄、病理类型无关(P>0.05)。RHAMM与TPX2蛋白在卵巢上皮性癌中表达呈正相关(rs=0.446,P=0.001)。结论 RHAMM与TPX2可能共同参与卵巢上皮性癌的发生与发展;RHAMM与TPX2有望成为卵巢上皮性癌预后评估的指标。
Objective To investigate the expression of hyaluronanmediated cell migration receptor (RHAMM) and Xklp2 target protein (TPX2) protein in epithelial ovarian cancer and its relationship with clinicopathological features. Methods 51 cases of epithelial ovarian cancer (group A), 20 cases of epithelial ovarian borderline tumor (group B), 22 cases of epithelial ovarian benign tumor (group C) and 12 cases of normal ovary were detected by EnVision immunohistochemical method. Expression of RHAMM and TPX2 proteins in tissues (group D). Results The positive rate of RHAMM and TPX2 protein expression in group D was not significantly higher than that in group D (P <0.05). The positive expression rates of RHAMM and TPX2 in group C, group B and group A were 22.7% and 9.1%, 30.0% and 55.0%, 88.2% and 86.3% Statistical significance (P <0.01). The expression of RHAMM in group A was correlated with pathological stage and lymph node metastasis (P <0.05), but not with age, pathological type and histological grade (P> 0.05). The expression of TPX2 protein was correlated with pathological stage, histological grade and lymph node metastasis <0.05), but not with age and pathological type (P> 0.05). RHAMM and TPX2 protein expression in epithelial ovarian cancer was positively correlated (rs = 0.446, P = 0.001). Conclusion RHAMM and TPX2 may participate in the occurrence and development of epithelial ovarian cancer. RHAMM and TPX2 are expected to be prognostic indicators of epithelial ovarian cancer.