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中国科学报讯合肥工业大学一项研究发现,通过光热试剂在近红外光照射下产生的光热效应,能触发化疗药物从黏流态高分子纳米药物载体中超敏释放,显著增强对肿瘤生长的抑制效果。成果发表在《先进功能材料》期刊。最新研究发现,高分子纳米药物富集在肿瘤部位并被肿瘤细胞摄取后,需要从纳米载体中快速释放才能达到更有效的肿瘤杀伤效果,而目前临床使用的聚乳酸体系高分子纳米药物无法实现这一需求。该校纳米医学和生物材料团队通过包载光热试剂和化疗药物阿霉素得到共负载纳米体系,其内核高分子材料玻璃化转变温度低至-81.8℃。在近红外光照射5秒后,纳米颗粒溶液温度微弱上升0.5℃~1.5℃,并触发化疗药物的快超敏释放。实
China Science News Hefei University of Technology found that through photothermal effects of photothermal agents in near-infrared light irradiation can trigger chemosensitive hypersensitivity release from viscous fluid polymer nanomedicine carriers, significantly enhance the tumor growth Inhibitory effect. Results published in “advanced functional materials” journals. The latest study found that the polymer nano-drug enrichment in the tumor site and tumor cell uptake, the need for rapid release from the nano-carrier in order to achieve more effective tumor killing effect, and the clinical use of polylactic acid system of polymer nano-drug can not be achieved This need. The school of nanomedicine and biomaterials team co-loaded with photothermal agents and chemotherapeutic drug doxorubicin obtained nano-system, the core of the polymer glass transition temperature as low as -81.8 ℃. After 5 seconds of near infrared light irradiation, the temperature of the nanoparticle solution increased slightly by 0.5 ℃ ~ 1.5 ℃ and triggered the rapid hypersensitivity release of chemotherapeutic drugs. real