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目的：７５％ＮａＣｌ／６％右旋糖酐（ＨＳＤ）对平原创伤休克和低压舱模拟高原创伤休克均有很好的治疗作用，本实验目的是探讨ＨＳＤ对高原（西藏拉萨高原现场）创伤失血性休克急救作用及其量效关系。方法：初进高原大鼠２４只，分为生理盐水对照组（６只），ＨＳＤ４ｍＬ／ｋｇ，６ｍＬ／ｋｇ和８ｍＬ／ｋｇ治疗组（各６只），动物戊巴比妥钠（ｉｐ）麻醉，右侧股骨粉碎性骨折加放血（６０ｋＰａ维持７０ｍｉｎ）复制创伤失血休克模型，观察静脉一次输注上述几个剂量ＨＳＤ对创伤失血性休克大鼠血流动力学指标和动物存活时间的影响，以生理盐水作对照。结果：一次性静脉输注ＨＳＤ４ｍＬ／ｋｇ、６ｍＬ／ｋｇ、８ｍＬ／ｋｇ均能显著提升休克大鼠血压，改善包括左室内压（ＬＶＳＰ），左室内压最大变化速率（±ｄｐ／ｄｔｍａｘ），心肌最大收缩速度（Ｖｐｍ），心肌收缩向量环面积（Ｌｏ）在内的血流动力学指标，维持时间超过２ｈ，同时可明显延长休克动物的存活时间，其中４ｍＬ／ｋｇ效果不太明显，６ｍＬ／ｋｇ，８ｍＬ／ｋｇ效果较好，但这两剂量效果相当，无显著差异。结论：ＨＳＤ４～８ｍＬ／ｋｇ对高原创伤失血休克大鼠有较好的早期急救作用，剂量以６～８ｍＬ／ｋｇ较为合适。
OBJECTIVE: 75% NaCl / 6% dextran (HSD) has a good therapeutic effect on traumatic shock in the plains and traumatic shock in the altiplano at low altitude. The purpose of this experiment is to investigate the effects of HSD on traumatic hemorrhagic in the plateau (Lhasa Plateau, Tibet) Shock emergency function and its dose - effect relationship. Methods: Twenty-four rats were randomly divided into saline control group (n = 6), HSD4mL / kg, 6mL / kg and 8mL / kg treatment group , The right femoral comminuted fracture plus bleeding (6 0kPa for 70min) replicate traumatic hemorrhagic shock model and observe the effect of intravenous infusion of several doses of HSD on hemodynamic parameters and animal survival time in traumatic hemorrhagic shock rats , With saline as a control. Results: HSV 4mL / kg, 6mL / kg and 8mL / kg could significantly improve the blood pressure of shock rats and improve the effects of LVSP, ± dp / dtmax, Maximum velocity of contraction (Vpm) and myocardial systolic vector lobe (hemodynamic parameters), maintaining more than 2h, and can significantly prolong the survival time of shock animals, of which 4mL / kg effect is not obvious, 6mL / kg, 8mL / kg better effect, but the two dose effect is equivalent, no significant difference. CONCLUSION: HSD 4 ~ 8mL / kg has a good early emergency response to traumatic hemorrhagic shock in rats at high altitude, and the dose of 6 ~ 8mL / kg is suitable.