论文部分内容阅读
目的:评价脑胶质瘤术后行同步放化疗的疗效。方法:58例脑胶质瘤患者术后随机分为放疗组29例及放疗+化疗组29例。放疗组术后仅行三维适形放疗,总剂量DT 60 Gy/4～6周;放疗+化疗组给予同样三维适形放疗,并同步于术后10～15 d(平均12 d)开始行超选介入动脉灌注尼莫司汀化疗,每4周1次,每次2.5 mg.kg~(-1),共进行4～6次结束。结果:放疗+化疗组总有效率(肿瘤消失+肿瘤明显缩小)75.9%(22/29例),1年生存率(75.86%),2年生存率(51.72%),与放疗组相比差异有统计学意义(P<0.05);结论:脑胶质瘤术后行同步放化疗,对脑胶质瘤有明显疗效。
Objective: To evaluate the efficacy of concurrent chemoradiotherapy after glioma surgery. Methods: Fifty-eight patients with glioma were randomly divided into radiotherapy group (n = 29) and radiotherapy + chemotherapy group (n = 29). The patients in radiotherapy group received only three-dimensional conformal radiotherapy (DT 60 Gy / 4-6 weeks). The same three-dimensional conformal radiotherapy was given in the radiotherapy + chemotherapy group and was performed synchronously at 10-15 days (mean 12 days) Selected interventional arterial infusion of nimodipine chemotherapy, once every 4 weeks, each 2.5 mg.kg ~ (-1), a total of 4 to 6 times over. Results: The total effective rate (75.9% (22/29), 1-year survival rate (75.86%) and 2-year survival rate (51.72%) in radiotherapy + chemotherapy group were significantly lower than those in radiotherapy group (P <0.05). Conclusions: Concurrent chemoradiotherapy after glioma has obvious curative effect on glioma.