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白细胞介素2(IL-2)是免疫系统中的一种重要的免疫调节物质。IL-2及其受体不仅存在于外周组织也分布在脑的许多部位,参与对神经系统的调节。本文旨在研究IL-2是否调制痛觉信息的传递。在猫的脊髓背角记录了18个痛敏神经元。(1)侧脑室注射IL-2(930U/μl,20-100μl)94.4%的神经元(n=10)的电刺激外周神经引起的C反应受到明显的抑制,抑制时程4-25分钟。而静脉或脊髓表面局部经药,对C反应没有明显影响。(2)记录了5个神经元对辐射热(50℃)刺激下肢庶部诱发的反应。感受野局部注射IL-2(10—20μl),使伤害性热反应抑制了76%,但不影响轻触感受野引起的反应。纳洛酮可反转IL-2引起的伤害性反应的抑制。本实验表明,IL-2通过感受器水平的外周机制和脑干下行抑制机制参与脊髓痛觉信息的调制。
Interleukin 2 (IL-2) is an important immunomodulatory substance in the immune system. IL-2 and its receptors exist not only in peripheral tissues but also in many parts of the brain and are involved in the regulation of the nervous system. This article aims to investigate whether IL-2 modulates the delivery of pain-related information. 18 pain sensitive neurons were recorded in the spinal dorsal horn of the cat. (1) Electrical stimulation of 94.4% neurons (n = 10) induced by intracerebroventricular injection of IL-2 (930U / μl, 20-100μl) significantly inhibited C-reaction induced by peripheral nerves, minute. While the local drug on the surface of the vein or spinal cord, no significant effect on the C response. (2) The responses of five neurons to the lower extremities induced by radiant heat (50 ℃) were recorded. Feel the wild local injection of IL-2 (10-20μl), the harmful thermal response was inhibited by 76%, but does not affect the response to light touch receptive field. Naloxone reverses the inhibition of nociception induced by IL-2. This experiment shows that IL-2 is involved in the modulation of spinal allodynia information through the peripheral level of sensory receptors and the inhibitory mechanism of brainstem depression.