目的观察镉对胎鼠骨骼发育的影响。方法将孕6 d的孕鼠随机分成4组,一次性腹腔注射氯化镉,剂量依次为0、1、2、4 mg Cd/kg体重,处死孕20 d的孕鼠,取出胎鼠,检查胎鼠的发育情况,并对部分胎鼠行茜素红染色。结果不同组之间的胎鼠体重、颅臀长、头长存在着显著性差异,并随着体内染镉剂量的加大而减小;三种不同剂量染镉组的胎鼠骨骼发育明显落后于对照组,表现为未骨化或骨化范围明显小于对照组;露脑、脊柱裂、卷尾、脊柱侧弯、肋骨缺失、顶骨缺失和胸骨缺失等发育异常明显多于对照组。结论镉可以导致胎鼠骨骼发育明显迟缓和骨骼畸形。 Objective To observe the effect of cadmium on the development of fetal rat bone. Methods Pregnant rats at 6 and 6 weeks of gestation were randomly divided into 4 groups: one intraperitoneal injection of cadmium chloride, followed by 0, 1, 2, 4 mg Cd / kg body weight. The pregnant rats were sacrificed for 20 days. The development of fetal rats, and some fetal rats alizarin red staining. Results There were significant differences in fetal body weight, cranial buttock length and head length among different groups and decreased with the increase of cadmium dose in vivo. The skeletal development of fetal rat was significantly lagged behind in three cadmium groups In the control group, the range of no ossification or ossification was significantly smaller than that of the control group. The developmental abnormalities such as the brain, spina bifida, caudal spine, scoliosis, missing rib, apical bone defect and sternum were significantly more than those in the control group. Conclusion Cadmium can cause obvious delay in skeletal development and skeletal deformity in fetal rats.