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目的分析降钙素原(PCT)与C反应蛋白(CRP)在新生儿感染性黄疸中的临床应用价值。方法选取住院治疗的90例感染性黄疸患儿作为观察组,同时选取相匹配的非感染性黄疸患儿80例作为对照组,所有的患儿均给予检测PCT和CRP,分析对比PCT与CRP在感染性和非感染性黄疸患儿中的表达以及临床意义。结果观察组患儿治疗后PCT及CRP指标明显下降,与治疗前比较差异有统计学意义(P<0.01);观察组患儿治疗前PCT与CRP指标明显高于对照组治疗前患儿,差异有统计学意义(P<0.01)。重度患儿组PCT与CRP指标最高,其次是中度组和轻度组,差异有统计学意义(P<0.01)。PCT指标对感染性黄疸患儿的阳性检测率为82.22%,CRP为70.00%,两组指标联合阳性检测率为93.33%;PCT组与PCT联合CRP组阳性率比较、CRP组与PCT联合CRP组阳性率比较差异均有统计学意义(P<0.05)。结论 PCT与CRP可作为新生儿感染性黄疸早期诊断的可靠指标,联合动态监测PCT与CRP对监测病情变化、判断疾病预后及治疗疗效均有重要意义。
Objective To analyze the clinical value of procalcitonin (PCT) and C-reactive protein (CRP) in neonatal infectious jaundice. Methods Totally 90 children with infectious jaundice were selected as the observation group. Meanwhile, 80 matched non-infectious jaundice children were selected as the control group. All the children were given PCT and CRP, and the comparative PCT and CRP Expression of asymptomatic and noninfectious jaundice in children and its clinical significance. Results The scores of PCT and CRP in the observation group decreased significantly after treatment compared with those before treatment (P <0.01). The scores of PCT and CRP in the observation group before treatment were significantly higher than those in the control group before treatment There was statistical significance (P <0.01). The PCT and CRP indexes were the highest in severe children group, followed by moderate and mild group, the difference was statistically significant (P <0.01). The positive rate of PCT in children with infectious jaundice was 82.22% and CRP was 70.00%, the positive rate of PCT and PCT combined with CRP was 93.33% The positive rate of the difference was statistically significant (P <0.05). Conclusion PCT and CRP can be used as a reliable indicator of early diagnosis of neonatal infectious jaundice. Combined with dynamic monitoring of PCT and CRP, it is of great significance to monitor the prognosis and prognosis of patients with the disease.