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目的 比较两种三联疗法和两种四联疗法根除Hp感染的疗效。方法将Hp阳性PU280例随机分为三联组、四联组。三联组中A1组70例用奥美拉唑+阿莫西林+克拉霉素,A2组70例用奥美拉唑+阿莫西林+甲硝唑;四联组中B1组70例用雷贝拉唑+丽珠得乐+阿莫西林+呋喃唑酮,B2组70例用兰索拉唑+丽珠得乐+阿莫西林+呋喃唑酮。各组疗程均为1周,疗程结束4周后复查胃镜检测Hp。结果各组Hp根除率分别为A176.9%、A279.7%、B198.5%、B296.7%,三联组平均根除率为78.3%,四联组平均根除率为97.6%。四联组Hp根除率高于三联组(P<0.05),两种疗法组内比较均无统计学差异(P>0.05)。结论与三联疗法比较,四联疗法用于Hp感染的初治,具有根除率高、成本低、副反应小等特点,应作为首选。
Objective To compare the efficacy of two triple therapy and two quadruple therapies to eradicate Hp infection. Methods Hp positive PU280 cases were randomly divided into triple group, quadruple group. In the triad group, 70 cases were treated with omeprazole + amoxicillin + clarithromycin in group A1, 70 cases were treated with omeprazole + amoxicillin + metronidazole in group A2, 70 cases in group B1 Lazole + Livrosol + Amoxicillin + Furazolidone, B2 group of 70 patients treated with Lansoprazole + Livrosol + Amoxicillin + Furazolidone. Each course of treatment were 1 week, 4 weeks after the end of treatment review gastroscopy Hp. Results The eradication rates of Hp in each group were A176.9%, A279.7%, B198.5% and B296.7% respectively. The average eradication rate was 83.3% in triple group and 97.6% in quadruple group. The eradication rate of Hp in the quadruple group was higher than that in the triple group (P <0.05). There was no significant difference between the two groups (P> 0.05). Conclusion Compared with triple therapy, quadruple therapy is the first choice for treating Hp infection. It has the characteristics of high eradication rate, low cost and small side effects, which should be the first choice.