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出现进行性重度低血糖症是内毒素休克从可逆转向不可逆和死亡的一个代谢指标。这是由于糖元分解或糖元异生所产生的葡萄糖与其消耗之间平衡失调所引起,其机理尚未阐明。但下列事实提示肾上腺素能系统参与其中。1.选择肾上腺素能阻滞对休克时心血管系统代偿失调及其引起的死亡具有良好的保护作用。2.肾上腺素能平衡失调可产生低血糖综合症。3.内毒素可激活腺苷酸环化酶,提高细胞环磷酸腺苷的水平,从而改变α-受体的活性。
The occurrence of progressive severe hypoglycemia is a metabolic indicator of endotoxic shock from reversible to irreversible and death. This is due to glycogen breakdown or glycogen produced by abnormal glucose balance between its consumption caused by the imbalance caused by its mechanism has not yet been clarified. However, the following facts suggest that the adrenergic system is involved. 1. Adrenergic blockade has a good protective effect on cardiovascular decompensation and its death caused by shock. 2. Adrenergic imbalance can produce hypoglycemia syndrome. Endotoxin activates adenylate cyclase, which increases the level of cellular cyclic adenosine monophosphate and thereby changes the activity of the alpha-receptor.