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检测了5年前后肥胖组32例和正常对照组19例脂肪素水平,并评价IMT、HOMA-IR和HOMA-β。结果5年后O组和NC组WHR、总胆固醇(TC)、甘油三酯(TG)和空腹血糖(FBG)水平高于5年前,脂联素水平均低于5年前(P<0.05)。5年后O组、BF、FBG和HOMA-IR水平高于NC组,HDL-C和脂联素水平低于NC组(P<0.05)。多元逐步回归分析显示,脂联素与BF呈正相关;与HOMA-IR呈负相关。结论随着年龄增长,肥胖和正常对照组的脂联素水平均逐渐降低,肥胖患者更明显;低脂联素血症与IR密切相关。
The levels of adiponectin in 32 obese patients and 19 normal controls were measured before and after 5 years and IMT, HOMA-IR and HOMA-β were evaluated. Results After 5 years, the levels of WHR, total cholesterol (TC), triglyceride (TG) and fasting blood glucose (FBG) in O and NC group were higher than those before 5 years ). After 5 years, the level of O, BF, FBG and HOMA-IR in NC group were higher than those in NC group, and the levels of HDL-C and adiponectin in NC group were lower than those in NC group (P <0.05). Multiple stepwise regression analysis showed that adiponectin was positively correlated with BF and negatively correlated with HOMA-IR. Conclusion With age, adiponectin levels and adiponectin levels in obese and normal control groups are gradually decreased, obese patients more obvious; low adiponectin is closely related to IR.