作者收集15例耳鼓室硬化症的鼓膜标本,用扫描电镜进行研究,并与5例尸体的正常鼓膜及21耳分泌性中耳炎作鼓膜切开术时收集的标本进行对比观察。在全部鼓室硬化症的鼓膜标本中,见鳞状上皮正常,上皮下间隙变浅,其中含有很少纤维但有若干血管。病变主要侵及鼓膜固有层。纤细的纤维为具有不等程度纤维排列的均质性物质所取代,原纤维及纤维索呈分裂状,不规则地分散沉积于固有层。放射状纤维较环状纤维易于分辨。在有些标本上,整个固有层变成不成形的块状物,看不到纤维排列。在另一些区域内,在不成形块状物的背景上能看到结缔组织样细胞,紧紧 The authors collected 15 cases of eardrum sclerosis tympanic membrane specimens, scanning electron microscopy study, and with 5 cases of normal eardrum and 21 ears of otitis media for tympanotomy specimens collected for comparison. In all tympanic eardrum tympanic specimens, see normal squamous epithelium, shallow subepithelial space, which contains few fibers but there are a number of blood vessels. Lesions mainly invading the tympanic lamina propria. The slender fibers are replaced by homogenous substances with varying degrees of fiber arrangement. The fibrils and the fiber strands are split and irregularly dispersed and deposited on the lamina propria. Radial fibers easier to distinguish than the annular fibers. In some specimens, the entire laminar layer became an unformed block with no fiber alignment. In other areas, connective tissue-like cells can be seen on the background of unformed lumps, tightly