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应用放射免疫法测定了313例正常人,19例肝硬变腹水和17例肝肾综合征(HRS)患者血浆心钠素(ANP)的含量.结果表明,HRS患者ANP水平((?)±s)为854.5±96.0ng/L,明显高于正常人451.9±47.5ng/L,P<0.01;但与无肾功能损害的肝硬变腹水患者(825.3±90.6ng/L)之间无显著差异,P>0.05.肝硬变腹水患者血浆ANP与肾素、血管紧张素Ⅱ呈显著正相关,伴HRS时却无相关关系.提示HRS并不是因缺乏ANP所致,HRS时,肾脏对ANP的反应性可能进一步降低.
The levels of plasma ANP in 313 normal subjects, 19 cirrhotic patients with cirrhosis and 17 patients with hepatorenal syndrome (HRS) were determined by radioimmunoassay.The results showed that ANP level (±) in HRS patients s) was 854.5 ± 96.0ng / L, which was significantly higher than that of normal people (451.9 ± 47.5ng / L, P <0.01). However, there was no significant difference between the treatment group and the cirrhosis patients without renal dysfunction (825.3 ± 90.6ng / L) (P> 0.05) .Patients with liver cirrhosis ascites plasma ANP and renin, angiotensin Ⅱ was no significant correlation with HRS, suggesting that HRS is not due to the lack of ANP, HRS, renal ANP The reactivity may be further reduced.