对1例既往有抑郁发作后自然缓解，32岁开始短暂接触海洛因、冰毒、曲马多等多种精神活性物质，后持续大量服用1，4-丁内酯，同时伴随抑郁综合征表现而住院患者的诊治及随访情况进行介绍和分析。“,”To introduce and analyze about the diagnosis，treatment and follow-ups of a patient who were in remission after an episode of depressive syndrome. The patient once used heroin，methamphetamine， tramadol and other psychoactive substances for a short time since her age of 32 and continuously took 1,4 butyrolactone with high dose thereafter.