论文部分内容阅读
目的评价通窍救心油舌下给药治疗冠心病不稳定型心绞痛的疗效及安全性。方法选择冠心病不稳定型心绞痛患者118例,随机分为舌下组30例、口服组29例、外搽组31例及对照组28例。在西医标准疗法的基础上,舌下组舌下含服通窍救心油;口服组口服通窍救心油;外搽组用通窍救心油外搽人中穴;对照组口服硝酸异山梨酯片,心绞痛发作时可临时增加1次用药,各组均治疗7天。治疗前后观察每周心绞痛发作次数、胸痛程度积分、胸闷程度积分,并于治疗后评价患者心绞痛缓解时间疗效、心电图疗效及安全性。结果治疗后各组每周心绞痛发作次数、胸痛程度积分、胸闷程度积分、心绞痛缓解时间疗效、心电图疗效均较治疗前好转(P<0.05);治疗后舌下组心绞痛缓解时间总有效率与口服组、外搽组、对照组比较差异均无统计学意义,但舌下组每周心绞痛发作次数、胸痛程度积分、胸闷程度积分、心绞痛缓解时间显效率及心电图有效率均优于口服组与外擦组(P<0.0167),与对照组比较疗效相当。观察期间,对各组患者试验前后肝、肾功能,血、尿、便常规的异常结果进行了统计描述,各组均无加重。结论通窍救心油舌下给药治疗冠心病不稳定型心绞痛疗效确切且安全,在快速缓解心绞痛、减少心绞痛发作次数、减轻胸痛胸闷程度、改善心电图心肌缺血方面与硝酸异山梨酯片疗效相当,起效时间明显优于外搽及口服给药。
Objective To evaluate the efficacy and safety of Tongqiao rescue heart oil sublingual injection in the treatment of unstable angina pectoris. Methods 118 patients with unstable angina pectoris were randomly divided into sublingual group (30 cases), oral group (29 cases), Waishen group (31 cases) and control group (28 cases). On the basis of Western standard therapy, the sublingual group contained Tongqiao to relieve heart oil; the oral group orally administered Tongqiao to save the heart oil; the Waicha group used Tongqiao to save the heart oil from Waicha Zhongzhong; the control group received isosorbide dinitrate tablets and angina pectoris When temporarily increased by 1 time medication, each group were treated for 7 days. The number of angina attacks per week, the degree of chest pain, the degree of chest tightness were observed before and after treatment. The angina pectoris time, ECG efficacy and safety were evaluated after treatment. Results After treatment, the number of angina attacks per week, the degree of chest pain, the score of chest tightness, the time of angina pectoris relief and the efficacy of electrocardiogram were all better than those before treatment (P <0.05). The total effective rate of angina pectoris time after oral administration Group, Wa Wa group and control group, there was no significant difference between the two groups. However, the frequency of angina pectoris, the degree of chest pain, the degree of chest tightness, the effective time of angina pectoris and the effective rate of ECG in sublingual group were better than those in oral group and external group Rub group (P <0.0167), compared with the control group, the same effect. During the observation period, the abnormal results of liver, kidney function, blood, urine and routine before and after each group of patients were statistically described without any aggravation. Conclusion Tongqiao rescue heart oil sublingual administration of unstable angina pectoris of coronary heart disease is effective and safe. It has the same curative effect as isosorbide dinitrate tablets in relieving angina pectoris, reducing the number of angina pectoris, relieving chest pain and chest tightness, and improving myocardial ischemia. The onset time was significantly better than Waicha and oral administration.