肝细胞生长因子(HGF)是一种很强的刺激肝细胞增殖的丝裂原。HGF的单一受体c-Met是一跨膜蛋白,由原癌基因c- met编码。HGF激活c-Met,导致ras/致分裂素激活蛋白(MAP) 激酶、磷脂酰肌醇-3-激酶/蛋白激酶B等信号转导途径的级联激活,细胞发生一系列生物学效应,如分散、细胞运动、侵袭、细胞迁移以及最终转移等。 Hepatocyte growth factor (HGF) is a potent mitogen that stimulates hepatocyte proliferation. The single receptor for HGF, c-Met, is a transmembrane protein encoded by the protooncogene c-met. HGF activates c-Met, leading to the cascade activation of signal transduction pathways such as ras / mitogen activated protein (MAP) kinase, phosphatidylinositol 3-kinase / protein kinase B, etc. The cells undergo a series of biological effects such as Scatter, cell motility, invasion, cell migration and eventually metastasis.