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目的探讨人乳头瘤病毒(HPV)检测在宫颈非典型鳞状上皮细胞(ASCUS)患者的临床意义及应用价值。方法本文对本院2010—2013年的收治的116例ASCUS的患者进行HPV检测,并且采用宫颈细胞学对感染类型进行诊断。结果①阴道镜活检结果中,宫颈鳞癌3例,宫颈湿疣及CINⅠ共36例,宫颈炎症65例,CINⅡ~Ⅲ12例。②HPV-DNA检测结果显示,54例患者呈现HPV阳性,高危型37例;HPV阴性62例。③阴道镜下宫颈活检的患者,HPV阳性组与HPV阴性组的炎症、宫颈湿疣、CINⅠ、CINⅡ~III比较具有统计学意义(P<0.05)。④分型检测结果中,HPV低危型感染者与高危型HPV感染者宫颈湿疣、CINⅠ和宫颈癌检出率比较无统计学差异,但两者炎症和CINⅡ~Ⅲ病变检出率比较P<0.05,有统计学差异。结论 HPV检测是ASCUS患者分流的有效方法,尤其是高危型HPV感染的ASCUS患者的诊断具有一定指导意义。
Objective To investigate the clinical significance and value of human papillomavirus (HPV) detection in patients with cervical atypical squamous cell carcinoma (ASCUS). Methods In this paper, 116 cases of ASCUS admitted to our hospital from 2010 to 2013 were tested for HPV, and cervical cytology was used to diagnose the type of infection. Results ① colposcopy biopsy results, cervical squamous cell carcinoma in 3 cases, cervical condyloma and CIN Ⅰ in 36 cases, 65 cases of cervical inflammation, CIN Ⅱ ~ Ⅲ 12 cases. ② HPV-DNA test results showed that 54 patients showed HPV-positive, high-risk type 37 cases; HPV-negative 62 cases. ③ colposcopy cervical biopsy patients, HPV-positive group and HPV-negative group inflammation, cervical condyloma, CIN Ⅰ, CIN Ⅱ ~ III was statistically significant (P <0.05). ④The genotyping results showed that there was no significant difference in the detection rate of cervical condyloma, CINⅠand cervical cancer between HPV-infected persons with low-risk type and those with high-risk type HPV infection, but the positive rates of CINⅠand CINⅡ- 0.05, there is a statistical difference. Conclusion HPV testing is an effective method for shunting ASCUS patients, especially for ASCUS patients with high-risk HPV infection.