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目的探讨肾上腺髓质素与新生儿缺氧缺血性脑病的关系。方法以80例足月缺氧缺血性脑病患儿为对象,30例足月正常新生儿为对照,于生后1d内,(10~14)d取外周静脉血,用放射免疫法测定血浆肾上腺髓质素水平。结果(1)缺氧缺血性脑病轻、中、重度组血浆肾上腺髓质素水平较对照组明显升高(P<0.01);缺氧缺血性脑病轻度组血浆肾上腺髓质素水平显著低于中、重度组(P<0.01);缺氧缺血性脑病中度组血浆肾上腺髓质素水平较重度组明显降低(P<0.01);血浆肾上腺髓质素水平随缺氧缺血性脑病患儿病情程度的加重而有增高的趋势;(2)缺氧缺血性脑病中、重度组恢复期血浆肾上腺髓质素水平较急性期下降,差异有显著性(P<0.05,P<0.01),而轻度组差异无显著性(P>0.05)。结论肾上腺髓质素可能对新生儿缺氧缺血性脑病有保护作用;肾上腺髓质素可作为新生儿缺氧缺血性脑病严重程度的标志物。
Objective To investigate the relationship between adrenomedullin and neonatal hypoxic-ischemic encephalopathy. Methods 80 cases of full-term hypoxic-ischemic encephalopathy in children as the object, 30 cases of full-term normal newborns as a control, within 1d after birth, (10 ~ 14) d peripheral venous blood, plasma radioimmunoassay Adrenomedullin levels. Results (1) The levels of plasma adrenomedullin in mild, moderate and severe hypoxia-ischemic encephalopathy were significantly higher than those in control group (P <0.01). The levels of plasma adrenomedullin in mild hypoxic-ischemic encephalopathy group were significantly higher than those in control group (P <0.01). The level of plasma adrenomedullin in moderate hypoxic-ischemic encephalopathy group was significantly lower than that in severe severe hypoxia-ischemic encephalopathy group (P <0.01). The level of plasma adrenomedullin was associated with hypoxia-ischemic (2) In hypoxic-ischemic encephalopathy, the level of plasma adrenomedullin in convalescent group was lower than that in acute phase, the difference was significant (P <0.05, P < 0.01), while there was no significant difference in mild group (P> 0.05). Conclusion Adrenomedullin may have a protective effect on neonatal hypoxic-ischemic encephalopathy. Adrenomedullin may be used as a marker of the severity of neonatal hypoxic-ischemic encephalopathy.