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目的 :观察高原地区消化性溃疡患者体内氧自由基代谢指标的变化 ;方法 :在海拔 2 2 60 m的西宁地区选择了 35例胃溃疡和 2 8例十二指肠溃疡患者 ,进行了氧自由基代谢指标超氧化物歧化酶 ( SOD)、谷胱甘肽过氧化物酶 ( GSH- Px)活性和丙二醛 ( MDA)含量的测定 ,并与同一条件下的 5 0例健康人作为对照组进行了比较 ;结果 :与对照组比较 ,胃溃疡组和十二指肠溃疡组患者体内的 SOD、GSH- Px活性明显升高 ,同时伴有 MDA含量的显著下降 ;而胃溃疡组和十二指肠溃疡组相比较均无显著性差异 ;结论 :在高原地区氧自由基代谢指标的变化与消化性溃疡的发生与发展密切相关。
OBJECTIVE: To observe the changes of oxygen free radical metabolism in patients with peptic ulcer in plateau area.Methods: 35 cases of gastric ulcer and 28 cases of duodenal ulcer were selected in Xining, an area of 2260 m altitude, The basal metabolic indices SOD, GSH-Px and MDA were measured and compared with those of healthy subjects under the same conditions The results showed that compared with the control group, the activities of SOD and GSH-Px in gastric ulcer group and duodenal ulcer group were significantly increased, accompanied by a significant decrease of MDA content; while gastric ulcer group and ten There was no significant difference between the two groups in the ulcer group. Conclusion: The changes of oxygen free radical metabolism in the plateau area are closely related to the occurrence and development of peptic ulcer.